Yohimbine is a natural compound derived from the bark of the Yohimbe tree (Pausinystalia yohimbe), native to West and Central Africa. It is commonly used as a fat loss supplement due to its ability to increase the release of fatty acids from fat cells, particularly in stubborn fat areas like the lower belly and thighs. This effect occurs because yohimbine blocks alpha-2 adrenergic receptors, which are involved in inhibiting fat breakdown.

In addition to its fat-burning properties, Yohimbine is also known for its stimulant effects, boosting energy, alertness, and exercise performance. It has been used to treat erectile dysfunction by improving blood flow and may have mild aphrodisiac effects.